WebSeveral nonpeptide CCR1 receptor antagonists that showed high affinity for human CCR1 receptors have been identified; however, their effectiveness in animal models of inflammatory diseases has been scarcely demonstrated, probably due to species selectivity of the antagonists. WebCCR1 is a chemokine receptor expressed on monocytes, T cells, dendritic cells, and neutrophils that interacts with multiple ligands–including CCL3 (macrophage inflammatory protein-1α, MIP-1α), CCL5 (RANTES, regulated on activation, normal T-cell expressed and secreted), CCL7 (monocyte chemotactic protein-3, MCP-3), CCL14 (hemofiltrate C-C …
CCR1 antagonists SpringerLink
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